Bullon P, Machuca G, Martinez Sahuquillo A, Rojas J, Lacalle J R, Rios J V, Velasco E
Department of Periodontology and Oral Medicine, School of Dentistry, University of Seville, Spain.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Mar;79(3):300-4. doi: 10.1016/s1079-2104(05)80223-9.
Gingival overgrowth induced by nifedipine has been extensively reported. This finding, however, does not apply to gingival size changes caused by other calcium antagonists such as diltiazem. We studied the gingiva of 13 subjects with ischemic cardiopathy who had been treated with diltiazem and established two control groups: (1) a healthy group of 12 patients and (2) a group of 10 patients with ischemic cardiopathy and concomitant treatment similar to that applied to the diltiazem group except that they had not been administered any type of calcium antagonists. The size of the gingiva around the six anterior teeth was measured on plaster models of the upper and lower jaws. Significantly higher scores of the size of the gingiva were found when patients treated with diltiazem were compared with the patients in the other two groups (p < 0.05) gingiva were found when patients treated with diltiazem were compared with the patients in the other two groups (p < 0.05) and also when interproximal (p < 0.05) and vestibular (p < 0.05) sites were considered. We did not observe any significant difference in the plaque index of each group (p < 0.05); only bleeding after probing was found statistically different between the diltiazem and the nondiltiazem groups.
硝苯地平引起的牙龈增生已被广泛报道。然而，这一发现并不适用于其他钙拮抗剂（如地尔硫䓬）引起的牙龈大小变化。我们研究了13名接受地尔硫䓬治疗的缺血性心脏病患者的牙龈，并设立了两个对照组：（1）12名健康患者组成的健康组；（2）10名缺血性心脏病患者组成的组，其伴随治疗与地尔硫䓬组相似，但未给予任何类型的钙拮抗剂。在上、下颌石膏模型上测量了六颗前牙周围牙龈的大小。与其他两组患者相比，接受地尔硫䓬治疗的患者牙龈大小得分显著更高（p < 0.05），在考虑邻面（p < 0.05）和前庭（p < 0.05）部位时也是如此。我们未观察到每组菌斑指数有任何显著差异（p < 0.05）；仅探诊后出血在使用地尔硫䓬组和未使用地尔硫䓬组之间存在统计学差异。
