Bullon P, Machuca G, Martinez-Sahuquillo A, Rios J V, Rojas J, Lacalle J R
Department of Periodontology, School of Dentistry, University of Seville, Spain.
J Clin Periodontol. 1994 Apr;21(4):256-9. doi: 10.1111/j.1600-051x.1994.tb00314.x.
Gingival hyperplasia caused by the use of nifedipine has been extensively reported. In this paper, the gingiva of 18 patients suffering from cardiopathy and treated with nifedipine were compared with those of 10 patients with cardiac disorders who had not been treated with calcium antagonists and with a no-treatment group of 12 patients. Nifedipine produced gingival hyperplasia, although patients who had not been treated with calcium antagonists also had mild hyperplasia. Hyperplasia first appeared in the interproximal areas, an observation which may be important for early detection. There was a direct correlation between the degree of hyperplasia and the bacterial plaque score. When we studied the influence of administration time and dose of nifedipine with the degree of hyperplasia, no statistically significant differences were found.
使用硝苯地平引起牙龈增生的情况已有大量报道。本文将18例患有心脏病并接受硝苯地平治疗的患者的牙龈，与10例未接受钙拮抗剂治疗的心脏病患者以及12例未治疗的对照组患者的牙龈进行了比较。硝苯地平会导致牙龈增生，尽管未接受钙拮抗剂治疗的患者也有轻度增生。增生首先出现在邻面区域，这一观察结果对早期检测可能很重要。增生程度与菌斑评分之间存在直接相关性。当我们研究硝苯地平的给药时间和剂量对增生程度的影响时，未发现统计学上的显著差异。
