Chinn H, Chernoff D N, Migliorati C A, Silverman S, Green T L
Division of Oral Medicine, UCSF, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jun;79(6):710-4. doi: 10.1016/s1079-2104(05)80305-1.
Histoplasmosis is a fungal infection caused by the organism Histoplasma capsulatum. Disseminated disease usually occurs in immunosuppressed patients or in patients with chronic illnesses. Although relatively uncommon, histoplasmosis has been reported in patients with AIDS, and oral lesions have been noted on multiple sites and in various clinical presentations. We present two HIV-positive cases with oral lesions as the initial signs of histoplasmosis. Both patients responded well to IV amphotericin B but later suffered recurrences despite being maintained on systemic antifungal therapy.
组织胞浆菌病是由荚膜组织胞浆菌引起的真菌感染。播散性疾病通常发生在免疫抑制患者或慢性病患者中。虽然相对不常见，但艾滋病患者中已有组织胞浆菌病的报道，且在多个部位和各种临床表现中都发现了口腔病变。我们报告两例以口腔病变为组织胞浆菌病初始体征的HIV阳性病例。两名患者对静脉注射两性霉素B反应良好，但尽管接受全身抗真菌治疗，后来仍复发。
