Weinberg R A
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology in Cambridge, USA.
CA Cancer J Clin. 1994 May-Jun;44(3):160-70. doi: 10.3322/canjclin.44.3.160.
In the past 15 years, many of the mechanisms underlying the molecular origins of cancer have been uncovered, and a clear picture of the role of oncogenes and tumor suppressor genes in carcinogenesis has developed. This article reviews the mechanisms by which oncogenes and tumor suppressor genes participate in the creation of tumors.
在过去的15年里，许多癌症分子起源的潜在机制已被揭示，并且癌基因和肿瘤抑制基因在致癌过程中的作用也已形成清晰的认识。本文综述了癌基因和肿瘤抑制基因参与肿瘤形成的机制。
