Canti G, Lattuada D, Morelli S, Nicolin A, Cubeddu R, Taroni P, Valentini G
Department of Pharmacology, School of Medicine, University of Milan, Italy.
Cancer Lett. 1995 Jul 13;93(2):255-9. doi: 10.1016/0304-3835(95)03818-h.
Photodynamic therapy (PDT) is a relatively new cancer treatment modality that employs light excitation of a photosensitizer to yield cytotoxic oxygen-related species. In the present study we explored whether PDT would have therapeutic effect against doxorubicin-resistant murine tumors. We compared the efficacy of PDT with aluminium disulphonated phthalocyanine (A1S2Pc) and laser light on the doxorubicin-sensitive murine tumors, B16 melanoma (B16), L1210 leukemia (L1210), P388 lymphoma (P388) and the corresponding doxorubicin-resistant lines (B16/Dx, L1210/Dx and P388/Dx). Mice bearing L1210-L1210/Dx, P388-P388/Dx and B16-B16/Dx, were treated with 5 mg/kg of A1S2Pc and laser light (100 mW/cm2 x 10 min of exposure) or with doxorubicin (10 or 12 mg/kg i.v.). The results show that PDT is active versus all tumors while doxorubicin is effective only against the three sensitive tumor lines (L1210, P388 and B16). These observations suggest that PDT might be a beneficial alternative treatment for drug-resistant tumors.
光动力疗法（PDT）是一种相对较新的癌症治疗方式，它利用光敏剂的光激发产生细胞毒性氧相关物质。在本研究中，我们探究了光动力疗法对多柔比星耐药小鼠肿瘤是否具有治疗效果。我们比较了用二磺酸铝酞菁（A1S2Pc）和激光对多柔比星敏感的小鼠肿瘤（B16黑色素瘤（B16）、L1210白血病（L1210）、P388淋巴瘤（P388））以及相应的多柔比星耐药株（B16/Dx、L1210/Dx和P388/Dx）进行光动力疗法的疗效。对携带L1210-L1210/Dx、P388-P388/Dx和B16-B16/Dx的小鼠，用5mg/kg的A1S2Pc和激光（100mW/cm2×10分钟照射）或多柔比星（10或12mg/kg静脉注射）进行治疗。结果表明，光动力疗法对所有肿瘤均有活性，而多柔比星仅对三种敏感肿瘤株（L1210、P388和B16）有效。这些观察结果表明，光动力疗法可能是耐药肿瘤的一种有益替代治疗方法。
