Kleber C J, Putt M S
Health Science Research, School of Health Sciences, Indiana University-Purdue University, Fort Wayne 46805-1499, USA.
Caries Res. 1995;29(3):237-42. doi: 10.1159/000262075.
The effects of topically applied mouthrinses containing AlCl3, or AlK(SO4)2 on dental caries and plaque were investigated in a rat model. For comparison, NaF and a two-step treatment of AlCl3 and NaF were also tested. Six groups of 20 weanling rats were inoculated with Streptococcus sobrinus 6715 and provided a caries-inducing diet and distilled water ad libitum. Test agents were topically applied twice daily 5 days per week at a concentration of 0.037 mol/l in a mouthrinse vehicle and were compared with a vehicle control rinse and a distilled water control. After 10 weeks none of the treatments reduced plaque amounts relative to the controls. The AlCl3 and AlK(SO4)2 rinses significantly reduced both smooth-surface and sulcal caries by approximately 40%. The cariostatic activity of the aluminum rinses was equivalent to an equimolar NaF mouthrinse on smooth surface lesions, but was statistically less than NaF on sulcal caries. The two-step treatment with AlCl3 and NaF indicated numerically additive effects, but the results were not statistically better than with NaF alone. Dentine caries progression paralleled the enamel caries prevalence results. No deaths, toxicologic effects, or inhibition of growth rates were observed in any treatment group. This study confirmed that topically applied solutions of aluminum salts inhibited caries formation in the rat caries model and showed that the cariostatic activity of aluminum was maintained in a compatible mouthrinse vehicle.
在大鼠模型中研究了局部应用含AlCl3或AlK(SO4)2的漱口水对龋齿和牙菌斑的影响。为作比较，还测试了NaF以及AlCl3和NaF的两步治疗法。将六组每组20只断乳大鼠接种远缘链球菌6715，并随意提供致龋饮食和蒸馏水。测试剂以0.037 mol/l的浓度在漱口水载体中每日局部应用两次，每周5天，并与载体对照漱口水和蒸馏水对照进行比较。10周后，相对于对照组，没有一种治疗方法能减少牙菌斑量。AlCl3和AlK(SO4)2漱口水使平滑面和龈沟龋均显著减少了约40%。铝漱口水的防龋活性在平滑面病变上等同于等摩尔的NaF漱口水，但在龈沟龋上在统计学上低于NaF。AlCl3和NaF的两步治疗法显示出数值上的相加效应，但结果在统计学上并不比单独使用NaF更好。牙本质龋进展与釉质龋患病率结果平行。在任何治疗组中均未观察到死亡、毒理学效应或生长速率抑制。本研究证实，局部应用铝盐溶液可抑制大鼠龋齿模型中的龋齿形成，并表明铝的防龋活性在相容的漱口水载体中得以维持。
