铝浓度对大鼠龋齿形成的影响。

Effect of aluminum concentration on dental caries formation in the rat.

作者信息

Putt M S, Kleber C J

机构信息

Health Science Research Center, School of Health Sciences, Indiana University-Purdue University, Fort Wayne, Indiana 46805-1499, USA.

出版信息

Oral Dis. 1995 Jun;1(2):80-5. doi: 10.1111/j.1601-0825.1995.tb00164.x.

DOI:10.1111/j.1601-0825.1995.tb00164.x

PMID:7553390

Abstract

OBJECTIVE

Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on formation of smooth surface and sulcal caries in cariogenically challenged rats infected with Streptococcus sobrinus.

METHODS

Weanling rats, inoculated with S. sobrinus, were randomly assigned to six groups which were topically treated twice daily with water (treatment control), a NaF solution of 100 parts/10(6) F (positive control), or AIK(SO4)2 solutions containing 100, 1000, 2000, or 4000 parts/10(6) AI. Rats were fed a high-sucrose diet and distilled water ad libitum for 10 weeks, then the molars were scored for enamel and dentin caries.

RESULTS

Relative to the water control, NaF and all AI solutions significantly reduced prevalence of both smooth-surface and fissure caries. Protection by AI solutions was greater on smooth surfaces than sulcal areas. AI treatments reduced smooth surface scores by 49-71% and sulcal scores by 27-53%. For all comparisons the protective effect of the 100 parts/10(6) AI solution was less than solutions containing 1000 parts/10(6) AI or more. NaF and all AI solutions also significantly reduced the extent of lesions penetration into dentin.

CONCLUSIONS

Topically applied AI reduced the formation and progression of both smooth surface and sulcal caries and showed evidence of a dose response in a rat model infected with S. sobrinus.

摘要

目的

局部应用铝（Al）可减少具有原生微生物群的大鼠的窝沟龋，但尚未在感染致龋细菌的动物中研究其治疗活性和浓度效应。本研究调查了含有不同Al浓度的溶液对感染远缘链球菌的致龋性攻击大鼠光滑表面和龈沟龋形成的影响。

方法

接种远缘链球菌的断奶大鼠被随机分为六组，分别每日两次局部给予水（治疗对照）、100份/10⁶氟的氟化钠溶液（阳性对照）或含有100、1000、2000或4000份/10⁶铝的硫酸铝钾溶液。大鼠自由采食高糖饮食和蒸馏水10周，然后对磨牙的釉质和牙本质龋进行评分。

结果

相对于水对照组，氟化钠和所有铝溶液均显著降低了光滑表面龋和窝沟龋的患病率。铝溶液对光滑表面的保护作用大于龈沟区域。铝处理使光滑表面评分降低了49 - 71%，龈沟评分降低了27 - 53%。对于所有比较，100份/10⁶铝溶液的保护作用小于含有1000份/10⁶铝或更高浓度的溶液。氟化钠和所有铝溶液也显著降低了病变向牙本质的渗透程度。