Jenkins P J, Chew S L, Lowe D G, Afshart F, Charlesworth M, Besser G M, Wass J A
Department of Endocrinology, St Bartholomew's Hospital, London, UK.
Clin Endocrinol (Oxf). 1995 May;42(5):529-34. doi: 10.1111/j.1365-2265.1995.tb02673.x.
Lymphocytic hypophysitis is a rare disorder which usually affects women and is often associated with pregnancy. We reviewed our experience of this disorder in order to see whether these features were universal amongst our patients.
A retrospective review of case notes.
Four patients with histologically proven lymphocytic hypophysitis.
Each patient had undergone full radiological and biochemical assessment of anterior and posterior pituitary function.
Only one woman presented during pregnancy, one patient was a man with coexistent active acromegaly, and one progressed over 5 years to panhypopituitarism. In one further patient, histological analysis revealed normal anterior pituitary tissue adjacent to lymphocytic follicles.
Lymphocytic hypophysitis should be considered in the differential diagnosis of any patient with a pituitary mass. We suggest that the entire removal of such a mass is warranted both for accurate diagnosis and definitive treatment.
淋巴细胞性垂体炎是一种罕见疾病，通常影响女性，且常与妊娠相关。我们回顾了我们对该疾病的诊治经验，以了解这些特征在我们的患者中是否普遍存在。
病例记录的回顾性研究。
4例经组织学证实的淋巴细胞性垂体炎患者。
每位患者均接受了垂体前叶和后叶功能的全面影像学和生化评估。
仅1名女性在孕期发病，1例患者为男性，同时患有活动性肢端肥大症，1例在5年内进展为全垂体功能减退。在另外1例患者中，组织学分析显示淋巴细胞滤泡旁的垂体前叶组织正常。
对于任何患有垂体肿块的患者，鉴别诊断时均应考虑淋巴细胞性垂体炎。我们建议，为了准确诊断和明确治疗，保证完整切除此类肿块是必要的。
