Hermsdörfer J, Danek A, Winter T, Marquardt C, Mai N
Entwicklungsgruppe Klinische Neuropsychologie, Städtisches Krankenhaus München-Bogenhausen, Germany.
Exp Brain Res. 1995;104(1):126-34. doi: 10.1007/BF00229862.
A simple isometric motor task was used to quantify intended and unintended finger movements in two subjects (father and son) with persistent mirror movements. One hand voluntarily changed grip force between thumb and index finger at different amplitudes and frequencies, while the other hand was to maintain a constant force. During all experimental conditions the "steady" hand showed insuppressible, highly cross-correlated contractions, compatible with bilateral distribution of a single motor command to the spinal cord. However, these associated movements were not strictly mirror images, nor did they show a fixed relationship to the voluntary movements across experimental conditions. The ratio of mirror to voluntary movement ranged from 1.4 to 19.1% and from 3.4 to 78.4% in the two subjects and was directly related to voluntary strength and speed. At maximum speed, mirror activity tended to precede voluntary activity, while it was delayed in slow force changes. Comparable time lags were not found in control subjects instructed to simulate mirror movements. We conclude that neuronal mechanisms in addition to bilateral corticomotoneuronal connections are at work in persistent mirror movements.
使用一项简单的等长运动任务来量化两名患有持续性镜像运动的受试者（父亲和儿子）有意和无意的手指运动。一只手在不同幅度和频率下自主改变拇指和食指之间的握力，而另一只手则保持恒定的力。在所有实验条件下，“稳定”的手都表现出无法抑制的、高度相互关联的收缩，这与向脊髓发出的单一运动指令的双侧分布相一致。然而，这些关联运动并非严格的镜像，在不同实验条件下，它们与自主运动也没有固定关系。在两名受试者中，镜像运动与自主运动的比例分别为1.4%至19.1%和3.4%至78.4%，且与自主力量和速度直接相关。在最大速度时，镜像活动往往先于自主活动，而在缓慢的力量变化中则延迟。在被指示模拟镜像运动的对照受试者中未发现类似的时间滞后。我们得出结论，除了双侧皮质运动神经元连接外，神经元机制也在持续性镜像运动中起作用。
