司坦唑醇作为皮肤科的一种新型治疗药物。
Stanozolol as a novel therapeutic agent in dermatology.
作者信息
Helfman T, Falanga V
机构信息
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL 33101, USA.
出版信息
J Am Acad Dermatol. 1995 Aug;33(2 Pt 1):254-8. doi: 10.1016/0190-9622(95)90244-9.
Anabolic steroids are synthetic derivatives of testosterone that were developed in the 1950s in an attempt to dissociate the anabolic and androgenic effects of testosterone. The anabolic steroid stanozolol has been particularly helpful because it has one of the largest anabolic/androgenic ratios. In addition, stanozolol has substantial fibrinolytic properties. We discuss the safety profile and the use of stanozolol for a variety of clinical applications. Stanozolol is approved for use in the treatment of hereditary angioedema, but numerous reports have detailed the effectiveness of this agent in the treatment of urticaria, Raynaud's phenomenon, and, more recently, cryofibrinogenemia and lipodermatosclerosis. Side effects are mostly dose related and are preventable with appropriate follow-up.
合成代谢类固醇是睾酮的合成衍生物，于20世纪50年代开发，旨在分离睾酮的合成代谢和雄激素作用。合成代谢类固醇司坦唑醇特别有用，因为它具有最大的合成代谢/雄激素比率之一。此外，司坦唑醇具有显著的纤维蛋白溶解特性。我们讨论了司坦唑醇的安全性概况及其在各种临床应用中的使用。司坦唑醇被批准用于治疗遗传性血管性水肿，但大量报告详细阐述了该药物在治疗荨麻疹、雷诺现象以及最近的冷纤维蛋白原血症和脂膜炎方面的有效性。副作用大多与剂量相关，通过适当的随访是可以预防的。
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