Minoshima S, Frey K A, Foster N L, Kuhl D E
Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0028, USA.
J Comput Assist Tomogr. 1995 Jul-Aug;19(4):541-7. doi: 10.1097/00004728-199507000-00006.
Our goal was to examine regional preservation of energy metabolism in Alzheimer disease (AD) and to evaluate effects of PET data normalization to reference regions.
Regional metabolic rates in the pons, thalamus, putamen, sensorimotor cortex, visual cortex, and cerebellum (reference regions) were determined stereotaxically and examined in 37 patients with probable AD and 22 normal controls based on quantitative 18FDG-PET measurements. Following normalization of metabolic rates of the parietotemporal association cortex and whole brain to each reference region, distinctions of the two groups were assessed.
The pons showed the best preservation of glucose metabolism in AD. Other reference regions showed relatively preserved metabolism compared with the parietotemporal association cortex and whole brain, but had significant metabolic reduction. Data normalization to the pons not only enhanced statistical significance of metabolic reduction in the parietotemporal association cortex, but also preserved the presence of global cerebral metabolic reduction indicated in analysis of the quantitative data.
Energy metabolism in the pons in probable AD is well preserved. The pons is a reliable reference for data normalization and will enhance diagnostic accuracy and efficiency of quantitative and nonquantitative functional brain imaging.
我们的目标是研究阿尔茨海默病（AD）中能量代谢的区域保存情况，并评估PET数据归一化到参考区域的效果。
基于定量18FDG-PET测量，立体定向测定脑桥、丘脑、壳核、感觉运动皮层、视觉皮层和小脑（参考区域）的区域代谢率，并在37例可能患有AD的患者和22名正常对照中进行检查。在将顶颞联合皮层和全脑的代谢率归一化到每个参考区域后，评估两组之间的差异。
脑桥在AD中显示出最佳的葡萄糖代谢保存情况。与顶颞联合皮层和全脑相比，其他参考区域显示出相对保存的代谢，但有明显的代谢降低。将数据归一化到脑桥不仅增强了顶颞联合皮层代谢降低的统计学意义，还保留了定量数据分析中显示的全脑代谢降低的存在。
可能患有AD的患者脑桥中的能量代谢保存良好。脑桥是数据归一化的可靠参考，将提高定量和非定量功能性脑成像的诊断准确性和效率。
