Kasperska-Czyźyk T, Heding L G, Tronier B
Department III of Internal Diseases, Central Clinical Hospital, Warsaw, Poland.
Int J Pancreatol. 1995 Apr;17(2):167-71. doi: 10.1007/BF02788535.
In 14 patients with acute pancreatitis during 16 episodes of the disease the concentrations of blood glucose, serum insulin (IRI), C-peptide (CP), and proinsulin (Pro) were determined in the fasting state on d 1, 2, 3, 5, and 10 after the attack. The peptides were measured using RIAs, and for determination of CP two antibodies: Byk-Mallinckrodt's and more specific M-1221 Novo antibodies were used. Apart from sporadic rises in the initial period of the disease, the blood glucose level did not change significantly and had a decreasing trend. On d 1 the mean serum IRI level was 0.17 +/- 0.04 (SD) nM, and it decreased on d 5 to 0.06 +/- 0.04 nM, rising again to 0.11 +/- 0.15 nM on d 10. The serum Pro concentration was on the same days: 11.1 +/- 12.6, 4.2 +/- 2.4 and 7.5 +/- 10.8 pM, whereas the serum CP values determined with M-1221 antibodies were 0.48 +/- 0.50, 0.34 +/- 0.19, and 0.52 +/- 0.25 nM, respectively. However, when serum CP was determined using Byk-Mallinckrodt kits, the concentration on d 1 was 1.90 +/- 1.12 nM and over the following days it decreased to 1.08 +/- 0.98 nM on d 5 and on d 10 it was 1.11 +/- 0.46 nM.(ABSTRACT TRUNCATED AT 250 WORDS)
在14例急性胰腺炎患者病程中的16次发作期间，于发病后第1、2、3、5和10天的空腹状态下测定血糖、血清胰岛素（IRI）、C肽（CP）和胰岛素原（Pro）的浓度。采用放射免疫分析法测定这些肽类物质，测定CP时使用了两种抗体：拜耳 - 马林克罗特公司的抗体以及特异性更强的诺和诺德M - 1221抗体。除疾病初期偶尔升高外，血糖水平无显著变化且呈下降趋势。第1天血清IRI平均水平为0.17±0.04（标准差）nM，第5天降至0.06±0.04 nM，第10天又升至0.11±0.15 nM。同期血清Pro浓度分别为：11.1±12.6、4.2±2.4和7.5±10.8 pM，而用M - 1221抗体测定的血清CP值分别为0.48±0.50、0.34±0.19和0.52±0.25 nM。然而，当使用拜耳 - 马林克罗特试剂盒测定血清CP时，第1天浓度为1.90±1.12 nM，随后几天，第5天降至1.08±0.98 nM，第10天为1.11±0.46 nM。（摘要截短于250字）
