抗乙型肝炎表面抗原单克隆抗体的制备。
Production of monoclonal antibody against hepatitis B surface antigen.
作者信息
Tangkananond W, Charoensiriwatana W, Vanichanon A, Janejai N, Wetprasit N, Shewsuwan P, Pojanagaroon B, Saguanwonge S, Bhumisawasdi J, Jayavasu C
机构信息
Institute of Pre-Clinical Sciences, Faculty of Medicine, Thammasat University, Pratumthani, Thailand.
出版信息
J Med Assoc Thai. 1995 Jan;78(1):11-7.
HBV infection is a major health problem in Southeast Asia. Thailand is considered to be an endemic area of HBV infection(18). Prevalence of HBsAg carriers is 5.2 per cent in children, 9 per cent in adults and 5.6 per cent in pregnant women(19,20). We believe that the monoclonal antibody described in the present report will be useful to develop HBsAg-KIT for national serologic screening assay, as considered in terms of sensitivity, specificity and cost effectiveness.
乙肝病毒感染是东南亚地区的一个主要健康问题。泰国被认为是乙肝病毒感染的地方性流行地区（18）。乙肝表面抗原携带者在儿童中的患病率为5.2%，在成年人中为9%，在孕妇中为5.6%（19,20）。我们认为，就敏感性、特异性和成本效益而言，本报告中描述的单克隆抗体将有助于开发用于全国血清学筛查检测的乙肝表面抗原检测试剂盒。
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