0.3%氧氟沙星耳用溶液治疗慢性化脓性中耳炎和外耳道炎：一项临床微生物学研究。
The treatment of chronic suppurative otitis media and otitis externa with 0.3 per cent ofloxacin otic solution: a clinico-microbiological study.
作者信息
Supiyaphun P, Tonsakulrungruang K, Chochaipanichnon L, Chongtateong A, Samart Y
机构信息
Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Med Assoc Thai. 1995 Jan;78(1):18-21.
.3 per cent ofloxacin solution has been studied widely and has been proved to be safe in both animal and human studies. Ototoxicity and hair cell damage were not found in animal experiments. Ototopical treatment in both pediatric and adult patients was proved to be safe in previous studies. P. aeruginosa and S. aureus play the major role in both CSOM and OE, and most causative pathogens are susceptible to ofloxacin. This study showed that the use of 0.3 per cent ofloxacin otic solution was safe in both children and adults and yielded excellent clinical results.
0.3%氧氟沙星溶液已得到广泛研究，并且在动物和人体研究中均被证明是安全的。在动物实验中未发现耳毒性和毛细胞损伤。先前的研究证明，在儿科和成年患者中进行耳局部治疗是安全的。铜绿假单胞菌和金黄色葡萄球菌在慢性化脓性中耳炎和外耳道炎中起主要作用，并且大多数致病病原体对氧氟沙星敏感。本研究表明，0.3%氧氟沙星耳用溶液在儿童和成人中使用均安全，并产生了优异的临床效果。
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