局部用环丙沙星与联合使用环丙沙星治疗慢性化脓性中耳炎流脓的比较
Topical vs Combination Ciprofloxacin in the Management of Discharging Chronic Suppurative Otitis Media.
作者信息
Renukananda G S, U P Santosh, George Nitha Mary
机构信息
Professor & Unit Chief, Department of Otorhinolaryngology, J.J.M. Medical College, Davangere , Karnataka, India .
Professor, Department of Otorhinolaryngology, J.J.M. Medical College, Davangere , Karnataka, India .
出版信息
J Clin Diagn Res. 2014 Jun;8(6):KC01-4. doi: 10.7860/JCDR/2014/8038.4421. Epub 2014 Jun 20.
OBJECTIVES
To study the microbial flora and determine the efficacy of topical ciprofloxacin ear drops in comparison with combination of topical and oral ciprofloxacin as first line management in patients diagnosed with chronic suppurative otitis media.
MATERIALS AND METHODS
Prospective randomized interventional clinical trial on 100 patients who presented with an acute episode of CSOM to our outpatient department.
RESULTS
In our study, topical ciprofloxacin therapy was found to be an effective treatment for an acute on chronic otitis media as was the combination therapy though the overall recurrence rate was found to be more in the former group.
CONCLUSION
In the absence of systemic infection or serious underlying disease, topical antibiotics alone constitute first line treatment for most patients with chronic suppurative otitis media, finding no evidence that systemic antibiotics alone or in combination with topical preparations improve treatment outcomes compared with topical antibiotics alone.
目的
研究慢性化脓性中耳炎患者的微生物菌群，并比较局部使用环丙沙星滴眼液与局部和口服环丙沙星联合使用作为一线治疗方法的疗效。
材料与方法
对100例在我院门诊出现慢性化脓性中耳炎急性发作的患者进行前瞻性随机干预临床试验。
结果
在我们的研究中，发现局部使用环丙沙星治疗慢性中耳炎急性发作是一种有效的治疗方法，联合治疗也是如此，尽管前一组的总体复发率更高。
结论
在没有全身感染或严重基础疾病的情况下，对于大多数慢性化脓性中耳炎患者，单独使用局部抗生素构成一线治疗方法，没有证据表明单独使用全身抗生素或与局部制剂联合使用比单独使用局部抗生素能改善治疗效果。
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