来自绞股蓝的新型达玛烷型糖苷。
New dammarane-type glycosides from Gynostemma pentaphyllum.
作者信息
Piacente S, Pizza C, De Tommasi N, De Simone F
机构信息
Dipartimento di Chimica della Sostanze Naturali, Università degli Studi di Napoli, Federico II, Italy.
出版信息
J Nat Prod. 1995 Apr;58(4):512-9. doi: 10.1021/np50118a005.
Four novel dammarane glycosides were isolated from a MeOH extract of the aerial parts of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D nmr experiments, including 1H-1H correlation spectroscopy (COSY, HOHAHA, NOESY) and 1H-13C heteronuclear correlation (HETCOR). The aglycone moieties are the new dammarane-type triterpenes (20S)-3 beta,20,23 xi-trihydroxydammar-24-en-21-oic acid-21,23-lactone for 1, the corresponding epimer at C-20(20R) for 2, (20S)-dammar-23-ene-3 beta-20,25,26- tetraol for 3, and (20R)-dammar-25-ene-3 beta,20,21,24 xi-tetraol for 4.
从绞股蓝地上部分的甲醇提取物中分离出四种新的达玛烷型糖苷。通过一维和二维核磁共振实验对其结构进行了阐明，包括氢-氢相关光谱（COSY、HOHAHA、NOESY）和氢-碳异核相关（HETCOR）。苷元部分是新的达玛烷型三萜，化合物1为(20S)-3β,20,23ξ-三羟基达玛-24-烯-21-酸-21,23-内酯，化合物2为C-20位相应的差向异构体(20R)，化合物3为(20S)-达玛-23-烯-3β-20,25,26-四醇，化合物4为(20R)-达玛-25-烯-3β,20,21,24ξ-四醇。
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