来自莲雾的达玛烷皂苷。

Dammarane saponins from Zizyphus lotus.

作者信息

Renault J H, Ghedira K, Thepenier P, Lavaud C, Zeches-Hanrot M, Le Men-Olivier L

机构信息

Faculté de Pharmacie (URA au CNRS 492), Reims, France.

出版信息

Phytochemistry. 1997 Apr;44(7):1321-7. doi: 10.1016/s0031-9422(96)00721-2.

DOI:10.1016/s0031-9422(96)00721-2

PMID:9115699

Abstract

Four dammarane-type saponins were isolated by means of centrifugal partition chromatography from the root bark of Zizyphus lotus. Their structures were elucidated using a combination of 1D and 2D 1H and 13C NMR spectra and mass spectroscopy. One of these glycosides is the known jujuboside A. The others are three new dammarane saponins, identified as 3-O-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl (1-->3)-[alpha-L-rhamnopyranosyl(1-->2)]-alpha-L-arabinopyranosyl jujubogenin = jujuboside C, 3-O-alpha-L-rhamnopyranosyl (1-->2)-[beta-D-glucopyranosyl(1-->3)]-beta-D-galactopyranosyl lotogenin = lotoside I, and 3-O-alpha-L-rhamnopyranosyl(1-->2)-[beta-D-glucopyranosyl (1-->3)]-beta-D-glucopyranosyl lotogenin = lotoside II. Lotogenin is a new dammarane derivative identified as (15R, 16R, 20R, 22R)-16 beta, 22-epoxydammar-24-ene-3 beta, 15 alpha, 16 alpha, 20 beta-tetraol.

摘要

采用离心分配色谱法从埃及蜜枣的根皮中分离出四种达玛烷型皂苷。通过结合一维和二维氢谱和碳谱核磁共振光谱以及质谱对其结构进行了阐明。其中一种糖苷是已知的酸枣仁皂苷A。其他三种是新的达玛烷皂苷，分别鉴定为3 - O - β - D - 吡喃葡萄糖基(1→6)-β - D - 吡喃葡萄糖基(1→3)-[α - L - 吡喃鼠李糖基(1→2)]-α - L - 阿拉伯吡喃糖基酸枣皂苷元 = 酸枣仁皂苷C、3 - O - α - L - 吡喃鼠李糖基(1→2)-[β - D - 吡喃葡萄糖基(1→3)]-β - D - 吡喃半乳糖基洛托皂苷元 = 洛托皂苷I以及3 - O - α - L - 吡喃鼠李糖基(1→2)-[β - D - 吡喃葡萄糖基(1→3)]-β - D - 吡喃葡萄糖基洛托皂苷元 = 洛托皂苷II。洛托皂苷元是一种新的达玛烷衍生物，鉴定为(15R, 16R, 20R, 22R)-16β, 22 - 环氧达玛 - 24 - 烯 - 3β, 15α, 16α, 20β - 四醇。