来自绿僵菌的新型去甲基 destruxin B2，可抑制人肝癌细胞中乙肝病毒表面抗原的产生。
The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells.
作者信息
Chen H, Yeh S F, Ong G T, Wu S H, Sun C M, Chou C K
机构信息
Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
出版信息
J Nat Prod. 1995 Apr;58(4):527-31. doi: 10.1021/np50118a007.
We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.
我们检测了从绿僵菌培养基中制备的粗提物的抗病毒活性。鉴定出了八种活性环缩肽，它们对人肝癌Hep3B细胞中乙肝表面抗原（HBsAg）的产生具有强烈的抑制作用。从绿僵菌中分离出一种新化合物，去甲基环缩肽B2 [1]。该结构是根据其核磁共振和质谱数据确定的。
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