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γ-吲哚霉素酮,一种源自深海放线菌的新的腐霉素代谢产物。

Gamma-indomycinone, a new pluramycin metabolite from a deep-sea derived actinomycete.

作者信息

Schumacher R W, Davidson B S, Montenegro D A, Bernan V S

机构信息

Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.

出版信息

J Nat Prod. 1995 Apr;58(4):613-7. doi: 10.1021/np50118a024.

DOI:10.1021/np50118a024
PMID:7623040
Abstract

A new member of the pluramycin class of antibiotics, gamma-indomycinone [1], has been isolated along with the known compounds rubiflavinone C-1 [2] and beta-indomycinone [3] from the culture broth of a Streptomyces sp. obtained from a deep-sea sediment core. Each compound is composed of an anthraquinone-gamma-pyrone nucleus, but bears a different side-chain. Compounds 2 and 3 were identified by comparison of their spectral data with published data, while gamma-indomycinone [1] was characterized using 1H-nmr and mass spectrometry.

摘要

从深海沉积物岩芯中获得的一株链霉菌的培养液中,分离出了多球霉素类抗生素的一个新成员γ-吲哚霉素酮[1],以及已知化合物玉红黄酮C-1[2]和β-吲哚霉素酮[3]。每种化合物均由蒽醌-γ-吡喃酮核组成,但侧链不同。通过将化合物2和3的光谱数据与已发表的数据进行比较来鉴定它们,而γ-吲哚霉素酮[1]则通过1H-核磁共振和质谱进行表征。

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