海洋动物来源的 HDN19-252 中的 Saliniquinone 衍生物，Saliniquinones G-I 和 Heraclemycin E
Saliniquinone Derivatives, Saliniquinones G-I and Heraclemycin E, from the Marine Animal-Derived HDN19-252.
机构信息
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2021 Oct 14;19(10):575. doi: 10.3390/md19100575.
Four new anthraquinone derivatives, namely saliniquinones G-I (-) and heraclemycin E (), were obtained from the Antarctic marine-derived actinomycete HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds and showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative (MRCNS), with MIC values ranging from 3.1 to 12.5 μM.
从南极海洋来源的放线菌 HDN19-252 中，通过全球天然产物社会（GNPS）分子网络平台的指导，获得了四个新的蒽醌衍生物，即 saliniquinones G-I(-)和 heraclemycin E()。通过广泛的 NMR、MS 和 ECD 分析阐明了它们的结构，包括绝对构型。化合物和对 6 种测试的细菌菌株，包括耐甲氧西林凝固酶阴性葡萄球菌（MRCNS），表现出有希望的抑制活性，MIC 值范围为 3.1 至 12.5 μM。
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