Batista J S, Almeida R N, Bhattacharyya J
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Brazil.
J Ethnopharmacol. 1995 Mar;45(3):207-10. doi: 10.1016/0378-8741(94)01217-n.
An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When administered intraperitoneally the two agents exhibited significant analgesic effects. The activity of both dioclein and aqueous fraction apparently involves an opiate-like mechanism, since their analgesic action was attenuated by naloxone pretreatment.
从大花薯蓣乙醇提取物中获得的水相部分和薯蓣黄酮（5,2',5'-三羟基-6,7-二甲氧基黄酮），分别采用乙酸诱导扭体试验和甩尾试验，对小鼠和大鼠进行镇痛作用测试。腹腔注射时，这两种药物均表现出显著的镇痛作用。薯蓣黄酮和水相部分的活性显然涉及类阿片机制，因为纳洛酮预处理会减弱它们的镇痛作用。
