da Silveira e Sá Rita de Cássia, de Oliveira Leandra Eugênia Gomes, Nóbrega Franklin Ferreira de Farias, Bhattacharyya Jnanabrata, de Almeida Reinaldo Nóbrega
Department of Biology, Federal University of Juiz de Fora-UFJF, Juiz de Fora, 36036-900 Minas Gerais, Brazil.
J Biomed Biotechnol. 2010;2010:606748. doi: 10.1155/2010/606748. Epub 2010 Mar 25.
The acute treatment of mice with an ethanolic extract from the seed pod of Dioclea grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration produced a significant antinociceptive effect as displayed by the acetic acid-induced writhing test and the formalin test. The antinociception was observed through the first (neurogenic pain) and second (inflammatory pain) phases in the formalin test. The hot plate test did not show an increase in the antinociceptive latency whereas the motor performance was affected by the administration at 300 mg/kg at the beginning (30 minutes) of the observation period but not at later periods (60 and 120 minutes). These results suggest that EDgP has a central antinociceptive action and a possible anti-inflammatory activity in mice.
通过腹腔注射给予小鼠大花蝶豆种子荚乙醇提取物（EDgP），剂量分别为75、150和300mg/kg，急性处理后，在乙酸诱导的扭体试验和福尔马林试验中均产生了显著的抗伤害感受作用。在福尔马林试验中，在第一阶段（神经源性疼痛）和第二阶段（炎症性疼痛）均观察到了抗伤害感受作用。热板试验未显示抗伤害感受潜伏期增加，而在观察期开始时（30分钟）给予300mg/kg会影响运动性能，但在后期（60和120分钟）则不会。这些结果表明，EDgP在小鼠中具有中枢抗伤害感受作用和可能的抗炎活性。
