Dearfield K L
U.S. Environmental Protection Agency, Office of Pesticide Programs, Washington, DC 20460, USA.
Mutat Res. 1995 Aug;330(1-2):35-40. doi: 10.1016/0027-5107(95)00034-g.
With the evolution of genetic toxicology as a scientific discipline and the formation of the Environmental Mutagen Society (EMS), much thought was given to the study of chemicals in the human environment for their mutagenic effects. The Society's goal was to promote scientific investigation and dissemination of information related to genetic toxicology. Subsequently, the concern for chemically induced genetic damage in human germ cells and its potential impact on genetic diseases was detailed in the Committee 17 Report (1975). With new information on the involvement of genetic alterations in disease and on the ramifications of possible effects of exposures to environmental mutagens, it is becoming increasingly necessary to again focus our attention on the assessment of heritable genetic effects. Clearly, strategies for communication of genetic hazard/risk assessments to exposed individuals and to those charged with regulating environmental agents need to be developed.
随着遗传毒理学作为一门科学学科的发展以及环境诱变剂协会（EMS）的成立，人们对人类环境中的化学物质的诱变作用进行了深入思考。该协会的目标是促进与遗传毒理学相关的科学研究和信息传播。随后，委员会第17号报告（1975年）详细阐述了对人类生殖细胞中化学诱导的遗传损伤及其对遗传疾病潜在影响的关注。随着关于遗传改变在疾病中的作用以及接触环境诱变剂可能产生的影响的新信息不断涌现，我们越来越有必要再次将注意力集中在对可遗传遗传效应的评估上。显然，需要制定向受暴露个体以及负责监管环境因子的人员传达遗传危害/风险评估的策略。
