International Commission for Protection Against Environmental Mutagens and Carcinogens. Genetic risk extrapolation from animal data to human disease. A Taskgroup Report. No. 00105.
作者信息
Favor J, Layton D, Sega G, Wassom J, Burkhart J, Douglas G, Dearfield K, Brusick D
机构信息
Hazleton Washington Inc., Vienna, VA 22182-1699, USA.
出版信息
Mutat Res. 1995 Aug;330(1-2):23-34. doi: 10.1016/0027-5107(93)e0261-n.
PMID:7623868
Abstract
This report describes a model for producing quantitative genetic risk assessments for human populations. The model is patterned after current methods used in cancer risk analysis. The risk to humans is expressed as the number of additional dominant genetic diseases added to the existing genetic burden, in the offspring of the exposed individuals.
摘要
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