Bourke J B, McIllmurray M B, Mead G M, Langman M J
Lancet. 1978 Apr 1;1(8066):706-8. doi: 10.1016/s0140-6736(78)90814-0.
Drug histories were taken from 100 patients in their first attack of acute pancreatitis, and each was matched with a control subject of the same sex who was admitted to hospital as an emergency with acute abdominal pain, whose serum-amylase was within the normal range, and whose age was within three years of the pancreatitis patient's. The major differences between the patient groups was in the use of cardiovascular agents, and this was primarily due to a statistically significant excess of diuretic takers among the pancreatitis patients. There was an associated excess of intake of digoxin and antihypertensive and anti-anginal agents, but neither difference was statistically significant. Other categories of drugs showed no substantial differences. The difference between the pancreatitic patients and controls is almost entirely accounted for by takers of cyclopenthiazide with potassium chloride and of frusemide, especially the former. Further clinical and experimental evidence is required before the role of diuretics and/or potassium chloride in causing acute pancreatitis can be determined.
对100例首次发作急性胰腺炎的患者进行了用药史调查，每例患者均与一名对照者匹配，该对照者为因急性腹痛急诊入院的同性患者，其血清淀粉酶在正常范围内，年龄与胰腺炎患者相差不超过三岁。患者组之间的主要差异在于心血管药物的使用，这主要是因为胰腺炎患者中服用利尿剂的人数在统计学上显著过多。地高辛、抗高血压药和抗心绞痛药的摄入量也相应过多，但这两种差异均无统计学意义。其他类别的药物没有显著差异。胰腺炎患者与对照组之间的差异几乎完全是由服用环戊噻嗪加氯化钾和速尿的患者造成的，尤其是前者。在确定利尿剂和/或氯化钾在引起急性胰腺炎中的作用之前，还需要进一步的临床和实验证据。
