Jackson G, Pierscianowski T A, Mahon W, Condon J
Lancet. 1976 Dec 18;2(7999):1317-8. doi: 10.1016/s0140-6736(76)91970-x.
Six symptomless patients aged 64-84 (mean 72) years received antihypertensive therapy from their family doctors. Pretreatment systolic pressures ranged from 160 to 220 mm Hg and disastolic pressures from 80 to 120 mm Hg. Within one week of starting therapy all six patients were admitted as emergencies with epidoses of unconsciousness. Admission systolic pressures ranged from 80 to 150 mm Hg and diastolic pressures from 50 to 90 mm Hg. Before admission each patient had experiences symptoms of postural hypotension and had become housebound. After antihypertensive therapy was stopped, one patient had a residual left homonymous hemianopia but the others recovered completely. A raised systolic and distolic pressure is common in the elderly; potent antihypertensive treatment may seriously impair the quality of life and is often unecessary.
6名年龄在64至84岁(平均72岁)的无症状患者接受了家庭医生的抗高血压治疗。治疗前收缩压范围为160至220毫米汞柱,舒张压范围为80至120毫米汞柱。开始治疗后一周内,所有6名患者均因昏迷发作作为急诊入院。入院时收缩压范围为80至150毫米汞柱,舒张压范围为50至90毫米汞柱。入院前,每位患者都经历了体位性低血压症状,并且只能居家不出。停用抗高血压治疗后,1名患者遗留左侧同向性偏盲,但其他患者完全康复。收缩压和舒张压升高在老年人中很常见;强效抗高血压治疗可能会严重损害生活质量,而且往往没有必要。