Kaye K L, Munoz D G
University of Western Ontario, Faculty of Medicine, London, Canada.
Neurosci Lett. 1995 Apr 28;190(1):65-8. doi: 10.1016/0304-3940(95)11501-m.
The innervation of human cerebral blood vessels has been examined using synaptophysin, a marker of synaptic vesicles, and chromogranin A, a marker of large dense-core vesicles. The catecholaminergic marker tyrosine hydroxylase was used for comparison. Synaptophysin and tyrosine hydroxylase demonstrated a similar distribution of nerve fibers whereas chromogranin A terminals were only sparsely evident. Our results suggest that there is not a subset of nerve fibers in existence which has a distribution different than that of catecholaminergic fibers. Furthermore, in view of its unexpected sparse distribution, chromogranin A in the nervi vasorum is not likely to be a significant contributor to cerebral blood flow regulation.
利用突触囊泡标记物突触素和大致密核心囊泡标记物嗜铬粒蛋白A，对人类脑血管的神经支配进行了研究。使用儿茶酚胺能标记物酪氨酸羟化酶作为对照。突触素和酪氨酸羟化酶显示出相似的神经纤维分布，而嗜铬粒蛋白A终末仅稀疏可见。我们的结果表明，不存在分布与儿茶酚胺能纤维不同的神经纤维亚群。此外，鉴于其出人意料的稀疏分布，血管神经中的嗜铬粒蛋白A不太可能是脑血流调节的重要因素。
