Arieli G, Alteras I, Feuerman E J
J Invest Dermatol. 1979 Jan;72(1):33-4. doi: 10.1111/1523-1747.ep12530167.
Two dermatophytic agents, Trichophyton rubrum and Trichophyton mentagrophytes were used in the experimental inoculation of psoriatic lesions in 27 volunteer patients (13 males and 14 females with an age range from 17 to 72 yr). T. rubrum was inoculated in 14 patients and T. mentagrophytes (varietas granulare) in 13. For purposes of control in each patient the same agent was also inoculated on healthy skin. Results were noted once a week for a period of 1 mo. A positive response was found in 12 of the 14 patients inoculated with T. rubrum but only in 4 of the 13 inoculated with T. mentagrophytes. Healthy skin was found to have a positive response in only 5 cases, in 4 with T. rubrum, and in 1 with T. mentagrophytes. These results confirm the possibility of invasion of psoriatic lesions by dermatophytes and suggest that the coexistance of psoriasis and dermatophytic infection may be not always purely coincidental. The importance of the awareness of the presence of mycotic lesions and their possible spread with the application of steroid ointments under occlusive dressings in a psoriatic patient is stressed.
使用两种皮肤癣菌——红色毛癣菌和须癣毛癣菌，对27例志愿者患者（13名男性和14名女性，年龄在17至72岁之间）的银屑病皮损进行实验性接种。14例患者接种红色毛癣菌，13例接种须癣毛癣菌（颗粒变种）。为了在每位患者身上进行对照，同样的菌种也接种在健康皮肤上。连续1个月每周记录结果。接种红色毛癣菌的14例患者中有12例出现阳性反应，而接种须癣毛癣菌的13例中只有4例出现阳性反应。健康皮肤仅在5例中出现阳性反应，其中4例接种红色毛癣菌，1例接种须癣毛癣菌。这些结果证实了皮肤癣菌侵袭银屑病皮损的可能性，并表明银屑病与皮肤癣菌感染的共存可能并非总是纯粹的巧合。强调了银屑病患者中意识到真菌性皮损的存在及其在封闭敷料下应用类固醇软膏时可能传播的重要性。
