Baskova I P, Aguejouf O M, Azougagh-Oualane F, Zavalova L L, Basanova A V, Doutremepuich C
Laboratory of Hematology, Bordeaux University, France.
Thromb Res. 1995 Mar 15;77(6):483-92. doi: 10.1016/0049-3848(95)00024-0.
Piyavit, the novel pharmacological preparation from the medicinal leech (Hirudo medicinalis) contained the leech saliva, produces the potent arterial antithrombotic effect examined on experimental of Laser Induced Thrombus formation. Administrated orally into rats or injected subcutaneously as water extract, non-diluted or in 1600 times diluted, it inhibits statistically significant comparing with control platelet thrombus stimulated by laser beams. Its components, prostanoid fraction and purified enzyme destabilase, endo-epsilon-(gamma-Glu)-Lys-isopeptidase, also inhibit thrombus formation in statistically different manner, comparing with control. All the tested preparations inhibit platelet aggregation induced by ADP. The dependence of arterial antithrombotic effect on the leech prostanoid is discussed.
吡亚维特是一种源自医用水蛭（欧洲医蛭）的新型药物制剂，含有水蛭唾液，在激光诱导血栓形成实验中显示出强大的动脉抗血栓作用。以水提取物形式口服给予大鼠，或皮下注射，不稀释或稀释1600倍，与激光束刺激的对照血小板血栓相比，它具有统计学上显著的抑制作用。其成分，前列腺素部分和纯化酶去稳定酶，即内-ε-（γ-谷氨酰）-赖氨酸异肽酶，与对照相比，也以统计学上不同的方式抑制血栓形成。所有测试制剂均抑制ADP诱导的血小板聚集。文中讨论了动脉抗血栓作用与水蛭前列腺素的关系。
