Baskova I P, Zavalova L L, Basanova A V, Aquejouf O M, Azougagh-Oualane F, Doutremepuich C
Biokhimiia. 1995 Nov;60(11):1775-83.
The protective antithrombotic effects of piyavit, a novel pharmacological preparation from the medicinal leech, its water extract concentrated and diluted 1600-fold, the piyavit fraction containing leech prostanoids and highly purified destabilase, epsilon-(gamma-Glu)-Lys-isopeptidase isolated from the medicinal leech (Hirudo medicinalis), have been studied. All the preparations under study inhibited clot formation in rat mesanterium arterioles stimulated by laser energy, contained leech prostanoids immunoenzymatically identified as 6-keto-PgF1 alpha and inhibited platelet aggregation induced by ADP. The putative mechanism of their antithrombotic effect is discussed.
已对一种名为皮雅维特（piyavit）的新型药物制剂的抗血栓保护作用进行了研究。皮雅维特是从药用水蛭中提取的，其水提取物浓缩并稀释了1600倍，该制剂含有水蛭前列腺素和高度纯化的去稳定酶（一种从药用水蛭（医用水蛭）中分离出的ε-(γ-谷氨酰)-赖氨酸异肽酶）。所有研究的制剂均能抑制激光能量刺激的大鼠肠系膜小动脉中的血栓形成，免疫酶法鉴定其中含有水蛭前列腺素，鉴定结果为6-酮-前列环素F1α，并且能抑制二磷酸腺苷诱导的血小板聚集。文中还讨论了它们抗血栓作用的可能机制。
