2,3,7,8-四氯二苯并对二恶英（TCDD）对雌性斯普拉格-道利大鼠发情周期和排卵的影响。
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on estrous cyclicity and ovulation in female Sprague-Dawley rats.
作者信息
Li X, Johnson D C, Rozman K K
机构信息
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160, USA.
出版信息
Toxicol Lett. 1995 Aug;78(3):219-22. doi: 10.1016/0378-4274(95)03252-g.
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on estrous cyclicity and ovulation in Sprague-Dawley rats was examined. TCDD at a single oral dose of 10 micrograms/kg resulted in irregularity of cycles, characterized mainly as prolonged periods of diestrus. In rats cycling normally this dose of TCDD reduced the ovulatory rate and the number of ova recovered. The results suggest that TCDD is a reproductive toxin also in female rats, the mechanism of which is as yet unknown.
研究了2,3,7,8-四氯二苯并对二恶英（TCDD）对斯普拉格-道利大鼠发情周期和排卵的影响。单次口服剂量为10微克/千克的TCDD导致周期不规则，主要表现为动情间期延长。在正常发情周期的大鼠中，该剂量的TCDD降低了排卵率和回收的卵子数量。结果表明，TCDD对雌性大鼠也是一种生殖毒素，其作用机制尚不清楚。
Zotero 插件