贴壁细胞周围对透明质酸酶敏感的晕圈。它们在阻断淋巴细胞介导的细胞溶解中的作用。
Hyaluronidase-sensitive halos around adherent cells. Their role in blocking lymphocyte-mediated cytolysis.
作者信息
McBride W H, Bard J B
出版信息
J Exp Med. 1979 Feb 1;149(2):507-15. doi: 10.1084/jem.149.2.507.
Abstract
A variety of adherent sarcoma, carcinoma and normal cells are surrounded in vitro by thick, transparent zones (approximately equal to 9 micron thick) that spleen cells and a variety of other cells and particles cannot penetrate. Seven lymphoblastoid cell lines did not possess such halos. The presence of these halos around adherent fibrosarcoma cells appeared to protect them from lymphocyte-mediated cytolysis. Hyaluronidase treatment, which destroyed the halo and allowed lymphocytes to approach the tumor cell membrane, enhanced the cytotoxic action of immune but not of normal spleen cells. These observations, in addition to highlighting a little-known feature of the cell surface, may also be of general relevance to the in vitro and in vivo killing of tumor cells by immune effector cells.
摘要
多种贴壁肉瘤细胞、癌细胞和正常细胞在体外被厚厚的透明带（约9微米厚）包围，脾细胞以及多种其他细胞和颗粒无法穿透该透明带。七个淋巴母细胞样细胞系不具有这种晕环。贴壁纤维肉瘤细胞周围存在这些晕环似乎可保护它们免受淋巴细胞介导的细胞溶解。透明质酸酶处理破坏了晕环，使淋巴细胞能够接近肿瘤细胞膜，增强了免疫脾细胞而非正常脾细胞的细胞毒性作用。这些观察结果除了突出细胞表面一个鲜为人知的特征外，可能还与免疫效应细胞在体外和体内杀伤肿瘤细胞具有普遍相关性。
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本文引用的文献
1
The partition of solutes between buffer solutions and solutions containing hyaluronic acid.溶质在缓冲溶液和含透明质酸溶液之间的分配
Biochem J. 1961 Apr;78(4):827-33. doi: 10.1042/bj0780827.
2
Barrier around synovial cells in vitro.体外滑膜细胞周围的屏障。
Nature. 1967 Jun 10;214(5093):1159. doi: 10.1038/2141159a0.
3
On the pericellular zone of some mammalian cells in vitro.在体外某些哺乳动物细胞的细胞周区。
Exp Cell Res. 1968 Jan;49(1):181-93. doi: 10.1016/0014-4827(68)90530-2.
4
Novel hyaluronidase from streptomyces.来自链霉菌的新型透明质酸酶。
Biochim Biophys Acta. 1970 Mar 18;198(3):607-9. doi: 10.1016/0005-2744(70)90139-7.
5
On the reactions of human synovial cells exposed to homologous leucocytes in vitro.关于体外培养的人滑膜细胞与同源白细胞相互作用的研究
Clin Exp Immunol. 1970 Feb;6(2):211-25.
6
A controlled-environment culture system for high resolution light microscopy.一种用于高分辨率光学显微镜的可控环境培养系统。
Exp Cell Res. 1971 Sep;68(1):144-8. doi: 10.1016/0014-4827(71)90596-9.
7
Lacunae in erythrocyte monolayers induced by adherent leukocytes.黏附白细胞诱导红细胞单层中的腔隙形成。
Nature. 1974 Jan 4;247(5435):57-8. doi: 10.1038/247057a0.
8
9
Cellular interactions in morphogenesis of epithelial mesenchymal systems.上皮-间充质系统形态发生中的细胞相互作用。
J Cell Biol. 1974 Oct;63(1):343-9. doi: 10.1083/jcb.63.1.343.
10
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
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