Moroson H, Nowakowski J, Schechter M
Int J Radiat Biol Relat Stud Phys Chem Med. 1978 May;33(5):473-82. doi: 10.1080/09553007814550381.
The effect of local X-irradiation of a syngeneic carcinoma of fibrosarcoma growing in the leg of W/Fu rats on the ability of host spleen lymphocytes to kill syngeneic and allogeneic tumour cells in vitro was examined. Lymphocytotoxicity was found to be enhanced one day after local X-irradiation (4000 R) when compared with unirradiated tumour-bearing rats (p = 0.05 to 0.01). This enhancing effect of local irradiation was not observed when the lymphocytes were tested 1 week or later after X-irradiation, nor when normal legs of non-tumour bearing rats were irradiated. Mechanisms which might possibly explain these results are a reduction in release of tumour-specific antigen which can act as an inhibitor of cell-mediated cytotoxicity, or depletion of suppressor cells in the lymphocyte population. These findings may be relavant to clinical studies of cellular immunity in patients undergoing radiotherapy of malignant tumours.
研究了对生长在W/Fu大鼠腿部的同基因纤维肉瘤癌进行局部X线照射后，宿主脾淋巴细胞在体外杀伤同基因和异基因肿瘤细胞能力的影响。与未照射的荷瘤大鼠相比，局部X线照射（4000伦琴）后一天发现淋巴细胞毒性增强（p = 0.05至0.01）。当在X线照射后1周或更晚测试淋巴细胞时，未观察到局部照射的这种增强作用，对未荷瘤大鼠的正常腿部进行照射时也未观察到。可能解释这些结果的机制是可作为细胞介导细胞毒性抑制剂的肿瘤特异性抗原释放减少，或淋巴细胞群体中抑制细胞的耗竭。这些发现可能与恶性肿瘤放疗患者的细胞免疫临床研究相关。
