Sinkjaer T, Toft E, Hansen H J
Department of Informatics and Image Analysis, Aalborg University, Hospital for Treatment of Multiple Sclerosis, Ry, Denmark.
Acta Neurol Scand. 1995 Apr;91(4):239-46. doi: 10.1111/j.1600-0404.1995.tb06997.x.
The aim of the present study was to quantitate the Hoffmann (H-) reflex modulation in the soleus muscle of spastic multiple sclerosis patients during walking at different stimulus strengths, and to quantitate the influence of the excitation level of the soleus muscle on the H-reflex. The H-reflex modulation was quantified by the minimum H-reflex in the swing phase and the modulation index introduced by Yang et al. (1). Stimulus strengths were matched between subjects, and only stimuli intensities, which reflect modulation in the H-reflex with true neurophysiological origin, were used. Based on this approach, we found that the reflex modulation is impaired in moderate spastic patients at both a strong and a weak afferent input to the motoneuron pool in consistency with studies on severe spastic patients. This study concludes that the H-reflex modulation in the spastic patients is only related to the excitation level of the muscles, whereas both the excitation level and other factors than the excitation level are known to influence the H-reflex modulation in healthy subjects.
本研究的目的是定量测定痉挛型多发性硬化症患者在不同刺激强度下行走时比目鱼肌中霍夫曼（H-）反射的调制情况，并定量测定比目鱼肌兴奋水平对H反射的影响。H反射调制通过摆动期的最小H反射和Yang等人（1）引入的调制指数来定量。在受试者之间匹配刺激强度，并且仅使用反映具有真正神经生理学起源的H反射调制的刺激强度。基于这种方法，我们发现，与对重度痉挛患者的研究一致，中度痉挛患者在运动神经元池的强传入输入和弱传入输入时，反射调制均受损。本研究得出结论，痉挛患者的H反射调制仅与肌肉的兴奋水平有关，而在健康受试者中，已知兴奋水平和兴奋水平以外的其他因素均会影响H反射调制。
