Hertz G, Cataletto M, Feinsilver S H, Angulo M
Sleep Disorders Center, Winthrop University Hospital, State University of New York at Stony Brook 11501, USA.
Am J Med Genet. 1995 Mar 27;56(2):188-90. doi: 10.1002/ajmg.1320560215.
Polysomnographic recordings of 43 children and adults with Prader-Willi syndrome (PWS) were inspected and classified into 5 age groups. The effect of age and body mass index (BMI) on measures of breathing, oxygen saturation, and sleep efficiency were analyzed. Body mass index (BMI) increased significantly between early childhood and preadolescent groups. Subjecting the data to analysis of variance showed an overall significant effect of BMI but no age effect on breathing parameters and oxygen saturation. Increased BMI was associated with decreased oxygen saturation and with higher apnea/hypopnea index. Sleep efficiency index was significantly lower in adults than in young children, preadolescent, and adolescent groups. These findings emphasize the role of obesity in the development of sleep-related breathing abnormalities and nocturnal oxygen desaturation in patients with PWS.
对43名普拉德-威利综合征（PWS）患儿及成人进行了多导睡眠图记录，并将其分为5个年龄组。分析了年龄和体重指数（BMI）对呼吸、血氧饱和度及睡眠效率指标的影响。幼儿组和青春期前组之间的体重指数（BMI）显著增加。对数据进行方差分析显示，BMI对呼吸参数和血氧饱和度有总体显著影响，但年龄无影响。BMI增加与血氧饱和度降低及呼吸暂停/低通气指数升高有关。成人的睡眠效率指数显著低于幼儿、青春期前及青少年组。这些发现强调了肥胖在PWS患者睡眠相关呼吸异常及夜间血氧饱和度降低发展过程中的作用。
