Camfferman Danny, McEvoy R Doug, O'Donoghue Fergal, Lushington Kurt
Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, South Australia 5042, Australia.
Sleep Med Rev. 2008 Feb;12(1):65-75. doi: 10.1016/j.smrv.2007.08.005.
Prader Willi Syndrome (PWS) is a rare genetic disorder characterized by a range of physical, psychological and physiological abnormalities. PWS patients may also demonstrate a range of abnormalities of sleep architecture and of breathing during sleep, and excessive daytime sleepiness (EDS). In the general population EDS is associated with Obstructive Sleep Apnea Syndrome (OSAS). In PWS, by contrast, OSAS is unlikely to fully explain EDS and other factors, including hypothalamic dysfunction are likely to contribute. The present review examines OSAS and hypothalamic dysfunction and other contributing factors to EDS in PWS.
普拉德-威利综合征（PWS）是一种罕见的遗传性疾病，其特征是一系列身体、心理和生理异常。PWS患者在睡眠结构和睡眠期间的呼吸方面也可能表现出一系列异常，以及日间过度嗜睡（EDS）。在普通人群中，EDS与阻塞性睡眠呼吸暂停综合征（OSAS）有关。相比之下，在PWS中，OSAS不太可能完全解释EDS，其他因素，包括下丘脑功能障碍可能也有影响。本综述探讨了PWS中OSAS、下丘脑功能障碍以及导致EDS的其他因素。
