Fallon P G, Sturrock R F, Niang A C, Doenhoff M J
School of Biological Sciences, University of Wales, Bangor Gwynedd, United Kingdom.
Am J Trop Med Hyg. 1995 Jul;53(1):61-2.
There is a recent report of low efficacy of praziquantel (PZQ) treatment of human schistosomiasis in a new Schistosoma mansoni focus in northern Senegal. Biomphalaria pfeifferi snails with patent infections were collected from the area of the focus and transported to the United Kingdom. Groups of mice were infected with cercariae from this Senegalese isolate, or with laboratory-maintained Kenyan or Puerto Rican isolates. In two separate experiments, PZQ was less effective against the parasite from Senegal than against the two other geographic isolates. The reduced susceptibility of S. mansoni to PZQ in infected human populations has important implications for current schistosomiasis control programs.
最近有报道称，在塞内加尔北部一个新的曼氏血吸虫疫源地，吡喹酮（PZQ）治疗人类血吸虫病的疗效较低。从疫源地采集了感染有明显寄生虫的费氏扁卷螺，并运往英国。将几组小鼠分别感染来自这种塞内加尔分离株的尾蚴，或感染实验室保存的肯尼亚或波多黎各分离株的尾蚴。在两项独立实验中，吡喹酮对来自塞内加尔的寄生虫的疗效低于对其他两个地理分离株的疗效。曼氏血吸虫对吡喹酮的易感性降低，这对当前的血吸虫病控制计划具有重要意义。
