García-Rodríguez J A, García Sánchez J E, Trujillano I, García Sánchez E, García García M I, Fresnadillo M J
Department of Microbiology, Facultad de Medicina, Hospital Clinico Universitario, Salamanca, Spain.
Antimicrob Agents Chemother. 1995 May;39(5):1194-5. doi: 10.1128/AAC.39.5.1194.
The susceptibilities of 120 clinical isolates of Brucella melitensis and 3 reference strains of the same species to six fluoroquinolones (clinafloxacin, PD 117596, PD 131628, PD 138312, PD 140248, and ciprofloxacin) were examined by agar dilution MIC methodology. Clinafloxacin was the most active compound tested (MIC at which 50% of strains tested were inhibited [MIC50] and MIC90 of 0.06 micrograms/ml). Its level of activity was slightly higher than that of PD 117596 (MIC50 and MIC90 of 0.12 micrograms/ml). PD 131628 and ciprofloxacin were less active than clinafloxacin, with MIC50s ranging from 0.12 to 0.25 micrograms/ml and MIC90s of between 0.25 and 0.5 micrograms/ml for the two compounds. The activity levels of PD 138312 and PD 140248, with MIC50s ranging from 1 to 2 micrograms/ml and MIC90s of 4 to 8 micrograms/ml, were lower than those of the other fluoroquinolones tested.
采用琼脂稀释法测定了120株羊种布鲁氏菌临床分离株和3株同物种参考菌株对6种氟喹诺酮类药物（克林沙星、PD 117596、PD 131628、PD 138312、PD 140248和环丙沙星）的敏感性。克林沙星是所测试的活性最强的化合物（50%受试菌株被抑制时的最低抑菌浓度[MIC50]和MIC90为0.06微克/毫升）。其活性水平略高于PD 117596（MIC50和MIC90为0.12微克/毫升）。PD 131628和环丙沙星的活性低于克林沙星，这两种化合物的MIC50范围为0.12至0.25微克/毫升，MIC90在0.25至0.5微克/毫升之间。PD 138312和PD 140248的活性水平低于其他所测试的氟喹诺酮类药物，其MIC50范围为1至2微克/毫升，MIC90为4至8微克/毫升。
