García-Rodríguez J A, García-Sánchez J E, Trujillano-Martín I, García-Sánchez E, García-García M I, Fresnadillo M J
Department of Microbiology and Parasitology, Hospital Clinico Universitario, Facultad de Medicina, Salamanca, Spain.
J Chemother. 1994 Apr;6(2):102-6. doi: 10.1080/1120009x.1994.11741137.
We have tested the in-vitro activities of BAY y 3118, a new chlorofluoroquinolone, ciprofloxacin, sparfloxacin, streptomycin, tetracycline and rifampin against 59 strains of Brucella melitensis. BAY y 3118 (MIC90 0.12 mg/L) was twice as active as sparfloxacin and tetracycline (MIC90 0.25 mg/L). The activity of ciprofloxacin, rifampin and streptomycin (MIC90 0.5, 2, and 8 mg/L, respectively) was, respectively, four-, sixteen-, and more than sixty-fold lower than that of BAY y 3118.
我们测试了新型氯氟喹诺酮BAY y 3118、环丙沙星、司帕沙星、链霉素、四环素和利福平对59株羊种布鲁氏菌的体外活性。BAY y 3118（MIC90为0.12mg/L）的活性是司帕沙星和四环素（MIC90为0.25mg/L）的两倍。环丙沙星、利福平和链霉素（MIC90分别为0.5、2和8mg/L）的活性分别比BAY y 3118低四倍、十六倍和六十多倍。
