Dolan J W, Gatlin J E
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425, USA.
Biochem Biophys Res Commun. 1995 Jul 26;212(3):854-60. doi: 10.1006/bbrc.1995.2047.
The product of the Saccharomyces cerevisiae GAL11 gene, Gal11p, is required for the proper expression of a wide range of genes including many mating-type-specific genes. In this study Gal11p is shown to have a role in the induction of transcription by pheromone. Basal transcription of an a-specific gene is unaffected by loss of Gal11p but pheromone treatment fails to increase transcription. A haploid-specific gene is shown to retain pheromone-inducibility in the absence of Gal11p but the extent of induction is drastically reduced. Evidence is also presented that suggests the existence of strain differences that can alter the phenotype of gal11 mutants.
酿酒酵母GAL11基因的产物Gal11p，是包括许多交配型特异性基因在内的广泛基因正常表达所必需的。在本研究中，Gal11p被证明在信息素诱导转录中起作用。一个a特异性基因的基础转录不受Gal11p缺失的影响，但信息素处理不能增加转录。一个单倍体特异性基因在没有Gal11p的情况下仍保留信息素诱导性，但诱导程度大幅降低。也有证据表明存在菌株差异，可改变gal11突变体的表型。
