肥胖 Zucker 大鼠的肾功能与血流动力学研究
Renal function and hemodynamic study in obese Zucker rats.
作者信息
Park S K, Kang S K
机构信息
Department of Internal Medicine, Chonbuk National University Medical School, Chonju, Korea.
出版信息
Korean J Intern Med. 1995 Jan;10(1):48-53. doi: 10.3904/kjim.1995.10.1.48.
OBJECTIVES
To investigate the renal function and hemodynamic changes in obesity and hyperinsulinemia which are characteristics of type II diabetes.
METHODS
Studies were carried out in two groups of female Zucker rats. Group 1 rats were obese Zucker rats with hereditary insulin resistance. Group 2 rats were lean Zucker rats and served as controls. In comparison with lean Zucker rats, obese Zucker rats exhibited hyperinsulinemia but normoglycemia. Micropuncture studies and morphologic studies were performed in these rats.
RESULTS
Functional studies showed that obese Zucker rats exhibited increases in kidney weight and GFR(obese Zucker, 1.23 +/- .07)ml/min; lean Zucker, 0.93 +/- .03ml/min). Micropuncture studies revealed that the increase in GFR in obese Zucker rats was attributable to the increases in the single nephron plasma flow rate and glomerular transcapillary hydraulic pressure. The glomerular ultrafiltration coefficient was the same in both groups. Morphologic studies revealed that the increase in GFR in obese Zucker rats was associated with an increase in glomerular volume.
CONCLUSIONS
These results suggest that obesity and hyperinsulinemia, which are the characteristics of type II diabetes, can be associated with glomerular hyperfiltration and glomerular capillary hypertension.
目的
研究肥胖和高胰岛素血症（Ⅱ型糖尿病的特征）时的肾功能及血流动力学变化。
方法
对两组雌性 Zucker 大鼠进行研究。第 1 组大鼠为遗传性胰岛素抵抗的肥胖 Zucker 大鼠。第 2 组大鼠为瘦 Zucker 大鼠，作为对照。与瘦 Zucker 大鼠相比，肥胖 Zucker 大鼠表现为高胰岛素血症但血糖正常。对这些大鼠进行了微穿刺研究和形态学研究。
结果
功能研究表明，肥胖 Zucker 大鼠的肾脏重量和肾小球滤过率增加（肥胖 Zucker 大鼠，1.23±0.07）ml/min；瘦 Zucker 大鼠，0.93±0.03ml/min）。微穿刺研究显示，肥胖 Zucker 大鼠肾小球滤过率的增加归因于单个肾单位血浆流速和肾小球跨毛细血管液压的增加。两组的肾小球超滤系数相同。形态学研究显示，肥胖 Zucker 大鼠肾小球滤过率的增加与肾小球体积的增加有关。
结论
这些结果表明，肥胖和高胰岛素血症（Ⅱ型糖尿病的特征）可能与肾小球高滤过和肾小球毛细血管高血压有关。
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