Seyer-Hansen K, Hansen J, Gundersen H J
Diabetologia. 1980 Jun;18(6):501-5. doi: 10.1007/BF00261707.
Renal hypertrophy in rats with streptozotocin diabetes or after unilateal nephrectomy was studied by sterological techniques. -- After 4 days of diabetes total glomerular volume had increased by 30%, and after 47 days by 43%. Glomerular growth was more pronounced than whole kidney growth during the first 4 days, but subsequently whole kidney growth exceeded glomerular growth. In control rats glomerular volume was 4.9% of total kidney volume; after 4 days of diabetes it was 5.4% and after 47 days 4.1%. -- Proximal tubule length increased from 366 m/kidney in control rats to 447 m/kidney after 47 days of diabetes; tubular luminal diameter increased from 26.8 micrometer to 31.4 micrometer in the same rats. Tubular length and luminal diameter were, however, not increased after 4 days of diabetes. -- In unilaterally nephrectomised rats there was no early rapid glomerular growth. Glomerular fractional volume was 4.9% in controls, 4.4% at four days, and 4.2% at 24 days after nephrectomy. -- The results indicate a disturbed glomerulo-tubular balance in the early phases of diabetic renal hypertrophy.
采用体视学技术研究了链脲佐菌素诱导糖尿病大鼠及单侧肾切除大鼠的肾肥大情况。——糖尿病4天后，肾小球总体积增加了30%，47天后增加了43%。在最初4天，肾小球的生长比整个肾脏的生长更明显，但随后整个肾脏的生长超过了肾小球的生长。在对照大鼠中，肾小球体积占肾脏总体积的4.9%；糖尿病4天后为5.4%，47天后为4.1%。——近端肾小管长度从对照大鼠的366米/肾增加到糖尿病47天后的447米/肾；在相同大鼠中，肾小管管腔直径从26.8微米增加到31.4微米。然而，糖尿病4天后肾小管长度和管腔直径并未增加。——在单侧肾切除大鼠中，早期没有快速的肾小球生长。对照中肾小球分数体积为4.9%，肾切除后4天为4.4%，24天为4.2%。——结果表明，在糖尿病性肾肥大的早期阶段，肾小球-肾小管平衡受到干扰。
