Eberling J L, Nordahl T E, Kusubov N, Reed B R, Budinger T F, Jagust W J
Center for Functional Imaging, Lawrence Berkeley Laboratory University of California, Berkeley 94720, USA.
J Neuroimaging. 1995 Jul;5(3):178-82. doi: 10.1111/jon199553178.
The results of a positron emission tomography study of regional cerebral metabolic rates of glucose are reported for 8 healthy old subjects (mean age, 66 yr; standard deviation [SD], 5) and 9 young subjects (mean age, 27 yr; SD, 4.6) using a high-resolution positron emission tomograph and the glucose metabolic tracer 18F-fluorodeoxyglucose. Older subjects showed significantly lower cerebral metabolic rates than did the young subjects, in anterior, middle, and posterior temporal neocortex and in mesial temporal cortex, with the largest differences occurring in anterior temporal cortex (temporal pole). The current findings may reflect either decreases in regional cerebral metabolic rates for glucose that occur with normal aging, or early indications of cognitive dysfunction that is associated with age-related disorders.
报告了一项正电子发射断层扫描研究的结果，该研究使用高分辨率正电子发射断层扫描仪和葡萄糖代谢示踪剂18F-氟脱氧葡萄糖，对8名健康老年受试者（平均年龄66岁；标准差[SD]为5）和9名年轻受试者（平均年龄27岁；SD为4.6）的局部脑葡萄糖代谢率进行了研究。老年受试者在前颞叶新皮质、中颞叶新皮质、后颞叶新皮质和颞叶内侧皮质的脑代谢率显著低于年轻受试者，其中前颞叶皮质（颞极）的差异最大。目前的研究结果可能反映了正常衰老过程中发生的局部脑葡萄糖代谢率下降，或者是与年龄相关疾病相关的认知功能障碍的早期迹象。
