Harvey P D, Powchik P, Mohs R C, Davidson M
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
J Neuropsychiatry Clin Neurosci. 1995 Spring;7(2):207-12. doi: 10.1176/jnp.7.2.207.
This study characterized memory functions in geriatric schizophrenic inpatients with a battery of memory tests sensitive to neuropsychological impairments in either temporal or frontal brain regions. In patients clinically rated as cognitively impaired (n = 24), nearly all of these measures showed deficits relative to less impaired patients (n = 25). Factor analysis found consistent correlations between the tests and their putative cortical localization. Discriminant analysis suggested the pattern of impairments was not consistent with a generalized deficit. These results introduce the possibility, to be directly tested with neuropathological study, that the severe cognitive deficits in elderly schizophrenic patients are due to dysfunctions in either the temporal or frontal regions of the cerebral cortex, with the specific type of dysfunction varying across cases.
本研究通过一系列对颞叶或额叶脑区神经心理损伤敏感的记忆测试，对老年精神分裂症住院患者的记忆功能进行了特征描述。在临床评定为认知受损的患者（n = 24）中，几乎所有这些测量指标相对于受损较轻的患者（n = 25）都显示出缺陷。因子分析发现测试与其假定的皮质定位之间存在一致的相关性。判别分析表明，损伤模式与广泛性缺陷不一致。这些结果提出了一种可能性，有待通过神经病理学研究直接检验，即老年精神分裂症患者的严重认知缺陷是由于大脑皮质颞叶或额叶区域的功能障碍所致，具体功能障碍类型因病例而异。
