Dormehl I C, Oliver D W, Hugo N, Rossouw D
AEC Institute for Life Sciences, University of Pretoria, South Africa.
Nucl Med Biol. 1995 Apr;22(3):373-8. doi: 10.1016/0969-8051(94)00094-z.
Pharmacological interactions are important when nuclear medical procedures are applied to patients under drug therapy, or drug provocation. This study compares in baboon models (regional) cerebral blood flow [(r)CBF] results from 99mTc-HMPAO and 123I-iodoamphetamine [123I(IMP)] each with and without acetazolamide, the latter a suggested drug for testing cerebrovascular reserve. Expected differences in cerebral uptake were observed between the two radio-tracers without acetazolamide. The increase in tracer uptake resulting from acetazolamide is significantly enhanced for 123I(IMP), which could have diagnostic implications.
当核医学程序应用于接受药物治疗或药物激发的患者时，药物相互作用很重要。本研究在狒狒模型中比较了99mTc-HMPAO和123I-碘安非他明[123I(IMP)]在使用和不使用乙酰唑胺情况下的（局部）脑血流量[(r)CBF]结果，后者是一种用于测试脑血管储备的推荐药物。在不使用乙酰唑胺的情况下，观察到两种放射性示踪剂之间脑摄取存在预期差异。乙酰唑胺导致的示踪剂摄取增加在123I(IMP)中显著增强，这可能具有诊断意义。
