Clark D G, Tomas F M, Withers R T, Brinkman M, Berry M N, Oliver J R, Owens P C, Butler R N, Ballard F J, Nestel P J
CSIRO, Division of Human Nutrition, Adelaide, Australia.
Int J Obes Relat Metab Disord. 1995 Apr;19(4):245-52.
To compare different aspects of intermediary metabolism in self perceived 'small-eating' females and self-perceived near normal weight 'large-eating' females and relate the data to those reported for Pima Indians who have the world's highest prevalence of non-insulin dependent diabetes mellitus and obesity.
Make repeat measurements of rates of oxygen consumption, carbon dioxide production and blood metabolites in 'large-' and 'small-eating' females at rest, during different activities and after ingestion of a standardised liquid meal.
Nine self perceived, 'large-eating' females and nine self perceived 'small-eating' females.
Resting metabolic rates (RMR), respiratory quotient (RQ) values and plasma insulin, glucagon insulin-like growth factor (IGF-1), dehydroepiandrosterone sulphate (DHEA-SO4) and glucose.
RMR (adjusted for FFM) averaged 3891 +/- 93 J/min in the 'small-eaters' and 3375 +/- 107 J/min in the 'large-eaters' for ten consecutive measurements conducted at 30 min intervals during the control period for the measurement of the thermic effect of food. Over this period the average RQ for the 'small-eating' women (0.81) was significantly greater than that of the 'large-eating' women (0.78). The two groups responded similarly to an oral glucose tolerance test but the concentration of DHEA-SO4 in plasma was 35% higher in the 'small-eaters'.
The 'small-eating' women may have a greater risk of weight gain but they counteract this tendency by maintaining high activity levels.
比较自认为“食量小”的女性和自认为体重接近正常的“食量大”的女性中间代谢的不同方面，并将这些数据与皮马印第安人（世界上非胰岛素依赖型糖尿病和肥胖症患病率最高的人群）的相关数据进行关联。
对“食量大”和“食量小”的女性在静息状态、不同活动期间以及摄入标准化流食后重复测量耗氧率、二氧化碳产生率和血液代谢物。
九名自认为“食量大”的女性和九名自认为“食量小”的女性。
静息代谢率（RMR）、呼吸商（RQ）值以及血浆胰岛素、胰高血糖素、胰岛素样生长因子（IGF-1）、硫酸脱氢表雄酮（DHEA-SO4）和葡萄糖。
在测量食物热效应的对照期内，每隔30分钟连续测量十次，“食量小”的女性RMR（根据去脂体重调整）平均为3891±93焦耳/分钟，“食量大”的女性为3375±107焦耳/分钟。在此期间，“食量小”女性的平均RQ（0.81）显著高于“食量大”的女性（0.78）。两组对口服葡萄糖耐量试验的反应相似，但“食量小”女性血浆中DHEA-SO4的浓度高35%。
“食量小”的女性可能有更大的体重增加风险，但她们通过保持高活动水平来抵消这种趋势。
