Muff R, Born W, Fischer J A
Department of Orthopaedic Surgery, University of Zurich, Switzerland.
Eur J Endocrinol. 1995 Jul;133(1):17-20. doi: 10.1530/eje.0.1330017.
Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin are structurally related peptides with N-terminal 6-7 amino acid ring structures linked by a disulfide bridge and with amidated C-termini. Among the related bioactive peptides, the structures of the calcitonin receptor and subtypes thereof have been identified so far through molecular cloning. Cross-reaction between receptors of calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin, as well as overlapping biological actions, anticipate that the respective receptors belong to a family of G-protein-coupled receptors that include those of parathyroid hormone, secretin and vasointestinal peptide.
降钙素、降钙素基因相关肽、肾上腺髓质素和胰淀素是结构相关的肽，其N端有由二硫键连接的6 - 7个氨基酸的环状结构，C端酰胺化。在这些相关的生物活性肽中，降钙素受体及其亚型的结构目前已通过分子克隆得以鉴定。降钙素、降钙素基因相关肽、肾上腺髓质素和胰淀素的受体之间存在交叉反应，以及重叠的生物学作用，这预示着各自的受体属于G蛋白偶联受体家族，其中包括甲状旁腺激素、促胰液素和血管活性肠肽的受体。
