脑膜炎奈瑟菌的流行传播与抗原变异性
Epidemic spread and antigenic variability of Neisseria meningitidis.
作者信息
Achtman M
机构信息
Max-Planck Institut für molekulare Genetik, Berlin, Germany.
出版信息
Trends Microbiol. 1995 May;3(5):186-92. doi: 10.1016/s0966-842x(00)88918-0.
PMID:7627456
Abstract
Genetic variation of cell-surface antigens of serogroup A meningococci arises from horizontal genetic exchange. Most clonal variants are lost by clonal reduction during epidemic and pandemic spread, but in exceptional cases, genetic variants are rapidly fixed in the bacterial population by clonal replacement.
摘要
A群脑膜炎球菌细胞表面抗原的基因变异源于水平基因交换。大多数克隆变体在流行和大流行传播期间通过克隆减少而丢失，但在特殊情况下，基因变体通过克隆替代在细菌群体中迅速固定下来。
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