1984 - 1987年意大利境内引起疾病的脑膜炎奈瑟菌菌株间的遗传关系
Genetic relationships among strains of Neisseria meningitidis causing disease in Italy, 1984-7.
作者信息
Mastrantonio P, Congiu M E, Selander R K, Caugant D A
机构信息
Bacteriology and Medical Mycology Laboratory, National Institute of Health, Rome, Italy.
出版信息
Epidemiol Infect. 1991 Feb;106(1):143-50. doi: 10.1017/s0950268800056508.
Since 1984 a change in the epidemiological pattern of meningococcal disease in Italy has occurred with a predominance of Neisseria meningitidis of serogroup C (76%), serotype 2a and a high proportion of strains resistant to sulphonamides (71%). In order to understand better the epidemiology of the group C N. meningitidis strains responsible for the disease over the last years in Italy, we studied the genetic features of phenotypically closely related strains, by enzyme electrophoresis. The results showed that the genetic and the phenotypic characteristics of the 57 strains studied were similar, suggesting that spread of a single clone during recent years in our country. This result is in agreement with the circulation of strains typical of epidemic situations, despite the decreasing incidence of meningococcal disease in Italy.
自1984年以来，意大利脑膜炎球菌病的流行病学模式发生了变化，C群脑膜炎奈瑟菌占主导地位（76%），血清型为2a，且有很大比例的菌株对磺胺类药物耐药（71%）。为了更好地了解过去几年在意大利引起该病的C群脑膜炎奈瑟菌菌株的流行病学情况，我们通过酶电泳研究了表型密切相关菌株的遗传特征。结果表明，所研究的57株菌株的遗传和表型特征相似，这表明近年来在我国单一克隆在传播。尽管意大利脑膜炎球菌病的发病率在下降，但这一结果与流行情况下典型菌株的传播情况相符。
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