Jefferson J W, Kalin N H
JAMA. 1979 Mar 16;241(11):1134-6.
In normal volunteers whose conditions were stablized with lithium carbonate, there were no significant changes in serum lithium levels during a two-week period while they received 40 mg/day of furosemide. During another two-week period, a 50 mg/day dosage of hydrochlorothiazide did cause a significant rise in serum lithium levels. These observations suggest that a substantial amount of lithium and a loop diuretic may not require modification of the lithium dosage.
在服用碳酸锂病情稳定的正常志愿者中，当他们每天服用40毫克速尿时，血清锂水平在两周内没有显著变化。在另一个两周期间，每天服用50毫克氢氯噻嗪确实导致血清锂水平显著升高。这些观察结果表明，大量锂与一种袢利尿剂联用可能不需要调整锂的剂量。
